Title : The use of isolated enterocytes to study Phase I intestinal drug metabolism: validation with rat and pig intestine.

Pub. Date : 2011 Feb

PMID : 21121944






1 Functional Relationships(s)
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1 The Phase I metabolism of the established marker drugs: midazolam, bupropion and dextromethorphan were measured by LC-MS and confirmed the activities of the 3A, 2B and 2D families of CYP isoforms, respectively. Bupropion cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus