Title : Role of peroxisome proliferator-activated receptor {delta}/{beta} in hepatic metabolic regulation.

Pub. Date : 2011 Jan 14

PMID : 21059653






4 Functional Relationships(s)
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1 We demonstrate here that adenovirus-mediated liver-restricted PPARdelta activation reduces fasting glucose levels in chow- and high fat-fed mice. Glucose peroxisome proliferator activator receptor delta Mus musculus
2 The altered substrate utilization by PPARdelta also results in a secondary effect on AMP-activated protein kinase activation, which likely contributes to the glucose-lowering activity. Glucose peroxisome proliferator activator receptor delta Mus musculus
3 Collectively, our data suggest that PPARdelta controls hepatic energy substrate homeostasis by coordinated regulation of glucose and fatty acid metabolism, which provide a molecular basis for developing PPARdelta agonists to manage hyperglycemia and insulin resistance. Glucose peroxisome proliferator activator receptor delta Mus musculus
4 Collectively, our data suggest that PPARdelta controls hepatic energy substrate homeostasis by coordinated regulation of glucose and fatty acid metabolism, which provide a molecular basis for developing PPARdelta agonists to manage hyperglycemia and insulin resistance. Glucose peroxisome proliferator activator receptor delta Mus musculus