Title : Intracellular GSH depletion triggered mitochondrial Bax translocation to accomplish resveratrol-induced apoptosis in the U937 cell line.

Pub. Date : 2011 Jan

PMID : 20876229






1 Functional Relationships(s)
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1 Microscopic analysis and small interfering RNA treatment emphasized that cellular GSH efflux triggered Bax translocation to mitochondria, which resulted in the loss of mitochondrial membrane potential, ROS generation, and caspase 3 activation and thus triggered apoptosis. Glutathione caspase 3 Homo sapiens