Title : Nuclear receptor-mediated induction of CYP450 by antiretrovirals: functional consequences of NR1I2 (PXR) polymorphisms and differential prevalence in whites and sub-Saharan Africans.

Pub. Date : 2010 Dec 15

PMID : 20861742






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Darunavir, fosamprenavir, lopinavir, nelfinavir, tipranavir, efavirenz, and abacavir increased CYP3A4 and/or CYP2B6 promoter activity, some through constitutive androstane receptor but mainly through PXR. Nelfinavir nuclear receptor subfamily 1 group I member 2 Homo sapiens