Pub. Date : 2011 Jan
PMID : 20840866
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tyrosine phosphorylation of beta-catenin is implicated as a means for its release from E-cadherin complexes and correlates with enhanced transcriptional activity. | Tyrosine | catenin beta 1 | Homo sapiens |
| 2 | Herein, we demonstrate that inhibition of tyrosine phosphatases with pervanadate induced both c-src-dependent tyrosine phosphorylation and nuclear translocation of beta-catenin. | Tyrosine | catenin beta 1 | Homo sapiens |
| 3 | Moreover, ectopic expression of SHP-1 but not the inactive form of SHP-1 (C453S) inhibited src-induced tyrosine phosphorylation of beta-catenin on tyrosines 86 and 654. | Tyrosine | catenin beta 1 | Homo sapiens |
| 4 | Moreover, ectopic expression of SHP-1 but not the inactive form of SHP-1 (C453S) inhibited src-induced tyrosine phosphorylation of beta-catenin on tyrosines 86 and 654. | Tyrosine | catenin beta 1 | Homo sapiens |
| 5 | SHP-1 expression and mutations of tyrosine-86 and tyrosine-654 to phenylalanine significantly and similarly decreased the transactivation potential of beta-catenin on the TOPFLASH reporter. | Tyrosine | catenin beta 1 | Homo sapiens |
| 6 | SHP-1 expression as well as mutations of tyrosine-86 and tyrosine-654 to phenylalanine also significantly interfered with the association of beta-catenin with TBP. | Tyrosine | catenin beta 1 | Homo sapiens |
| 7 | In conclusion, SHP-1 negatively regulates beta-catenin transcriptional activity i) by dephosphorylating beta-catenin on tyrosines 86 and 654, ii) by impairing its capacity to interact with the basal transcriptional factor TBP and iii) by promoting beta-catenin degradation in a GSK3beta-dependent manner. | Tyrosine | catenin beta 1 | Homo sapiens |
| 8 | In conclusion, SHP-1 negatively regulates beta-catenin transcriptional activity i) by dephosphorylating beta-catenin on tyrosines 86 and 654, ii) by impairing its capacity to interact with the basal transcriptional factor TBP and iii) by promoting beta-catenin degradation in a GSK3beta-dependent manner. | Tyrosine | catenin beta 1 | Homo sapiens |
| 9 | In conclusion, SHP-1 negatively regulates beta-catenin transcriptional activity i) by dephosphorylating beta-catenin on tyrosines 86 and 654, ii) by impairing its capacity to interact with the basal transcriptional factor TBP and iii) by promoting beta-catenin degradation in a GSK3beta-dependent manner. | Tyrosine | catenin beta 1 | Homo sapiens |