Title : Differential signaling of the endogenous agonists at the beta2-adrenergic receptor.

Pub. Date : 2010 Nov 12

PMID : 20837485






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In this beta(2)AR sensor, norepinephrine caused signals that amounted to only 50% of those induced by epinephrine and the standard "full" agonist isoproterenol. Norepinephrine adrenoceptor beta 2 Homo sapiens
2 Furthermore, norepinephrine-induced changes in the beta(2)AR FRET sensor were slower than those induced by epinephrine (rate constants, 47 versus 128 ms). Norepinephrine adrenoceptor beta 2 Homo sapiens
3 We conclude that partial agonism of norepinephrine at the beta(2)AR is related to the induction of a different active conformation and that this conformation is efficient in signaling to G(s) and less efficient in signaling to beta-arrestin2. Norepinephrine adrenoceptor beta 2 Homo sapiens