Title : Arsenic trioxide induces apoptosis through JNK and ERK in human mesothelioma cells.

Pub. Date : 2011 Mar

PMID : 20799280






4 Functional Relationships(s)
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1 As2O3 induced apoptosis of NCI-H2052 cells, which was accompanied by activation of c-Jun NH2-terminal kinase (JNK)1/2, extracellular signal-regulated kinase (ERK)1/2, and caspase-3. Arsenic Trioxide caspase 3 Homo sapiens
2 zVAD-fmk, a broad-spectrum caspase inhibitor, inhibited As2O3-induced apoptosis and activation of caspase-3, but not that of JNK1/2 and ERK1/2. Arsenic Trioxide caspase 3 Homo sapiens
3 Small interfering RNAs (siRNAs) targeting JNK1/2 suppressed As2O3-induced caspase-3 activation and apoptosis, indicating that JNK1/2 regulate As2O3-induced apoptosis though caspase cascade. Arsenic Trioxide caspase 3 Homo sapiens
4 Small interfering RNAs (siRNAs) targeting JNK1/2 suppressed As2O3-induced caspase-3 activation and apoptosis, indicating that JNK1/2 regulate As2O3-induced apoptosis though caspase cascade. Arsenic Trioxide caspase 3 Homo sapiens