Title : Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent.

Pub. Date : 2010 Aug 20

PMID : 20727180






1 Functional Relationships(s)
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1 RESULTS: While low concentrations of nicotine induced activation of NF-kappaB, Akt, Bcl2, MAPKs, AP1 and IAPs in H1299, it failed to induce NF-kappaB in A549, and compared to H1299, almost 100 times higher concentration of nicotine was required to induce all other survival signals in A549. Nicotine AKT serine/threonine kinase 1 Homo sapiens