Title : Abrogating HSP response augments cell death induced by As2O3 in glioma cell lines.

Pub. Date : 2010 Jul

PMID : 20724260






1 Functional Relationships(s)
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1 RESULTS: It was showed that KNK437 (HSPs inhibitor) or HSF1 knockdown significantly enhanced cell death, MMP disruption, JNK phosphorylation and caspase-3 cleavage induced by ATO, which was accompanied by abrogation of HSPs induction, while heat pre-treatment with clear HSPs induction had strong protection on the effects mentioned above. Arsenic Trioxide caspase 3 Homo sapiens