Title : Mouse embryonic fibroblasts from CD38 knockout mice are resistant to oxidative stresses through inhibition of reactive oxygen species production and Ca(2+) overload.

Pub. Date : 2010 Aug 20

PMID : 20638362






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 CD38 is a multifunctional enzyme that has both ADP-ribosyl cyclase and cADPR hydrolase activities, being capable of cleaving NAD(+) to cyclic ADP ribose (cADPR) and hydrolyzing cADPR to ADPR. NAD CD38 antigen Mus musculus
2 It has been reported that there is markedly a reduction of cADPR and elevation of NAD in many tissues from CD38 knockout (CD38(-/-)) mice. NAD CD38 antigen Mus musculus
3 It has been reported that there is markedly a reduction of cADPR and elevation of NAD in many tissues from CD38 knockout (CD38(-/-)) mice. NAD CD38 antigen Mus musculus
4 We hypothesize that CD38 knockout may have a protective effect in oxidative stresses through elevating NAD and decreasing cADPR. NAD CD38 antigen Mus musculus