Pub. Date : 2010 Sep
PMID : 20580678
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Piceatannol induces Fas and FasL up-regulation in human leukemia U937 cells via Ca2+/p38alpha MAPK-mediated activation of c-Jun and ATF-2 pathways. | 3,3',4,5'-tetrahydroxystilbene | mitogen-activated protein kinase 14 | Homo sapiens |
| 2 | Piceatannol-induced apoptotic death of human leukemia U937 cells was characterized by increase in intracellular Ca(2+) concentration ([Ca(2+)]i), ERK inactivation, p38 MPAK activation, degradation of procaspase-8 and production of t-Bid. | 3,3',4,5'-tetrahydroxystilbene | mitogen-activated protein kinase 14 | Homo sapiens |
| 3 | Abolition of piceatannol-induced increase in [Ca(2+)]i abrogated p38 MAPK activation and up-regulation of Fas and FasL expression, but restored ERK activation and viability of piceatannol-treated cells. | 3,3',4,5'-tetrahydroxystilbene | mitogen-activated protein kinase 14 | Homo sapiens |
| 4 | Suppression of p38alpha MAPK or transfection of constitutively active MEK1 abolished piceatannol-induced Fas and FasL up-regulation. | 3,3',4,5'-tetrahydroxystilbene | mitogen-activated protein kinase 14 | Homo sapiens |
| 5 | Piceatannol treatment repressed ERK-mediated c-Fos phosphorylation but evoked p38alpha MAPK-mediated c-Jun and ATF-2 phosphorylation. | 3,3',4,5'-tetrahydroxystilbene | mitogen-activated protein kinase 14 | Homo sapiens |
| 6 | Taken together, our data indicate that Fas/FasL up-regulation in piceatannol-treated U937 cells is elicited by Ca(2+)/p38alpha MAPK-mediated activation of c-Jun and ATF-2, and suggest that autocrine Fas-mediated apoptotic mechanism is involved in piceatannol-induced cell death. | 3,3',4,5'-tetrahydroxystilbene | mitogen-activated protein kinase 14 | Homo sapiens |
| 7 | Taken together, our data indicate that Fas/FasL up-regulation in piceatannol-treated U937 cells is elicited by Ca(2+)/p38alpha MAPK-mediated activation of c-Jun and ATF-2, and suggest that autocrine Fas-mediated apoptotic mechanism is involved in piceatannol-induced cell death. | 3,3',4,5'-tetrahydroxystilbene | mitogen-activated protein kinase 14 | Homo sapiens |