Title : Role of melatonin in mucosal gastroprotection against aspirin-induced gastric lesions in humans.

Pub. Date : 2010 May

PMID : 20443220






2 Functional Relationships(s)
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1 Plasma gastrin levels were raised in subjects given melatonin or tryptophan plus ASA, but not in those with ASA alone. Tryptophan gastrin Homo sapiens
2 We conclude that melatonin and its precursor tryptophan given orally significantly reduce gastric lesions induced by ASA possibly due to (a) direct gastroprotective action of exogenous melatonin or that generated from tryptophan and (b) gastrin released from the gastric mucosa by melatonin or tryptophan. Tryptophan gastrin Homo sapiens