Title : Expression of oncogenic kinase Bcr-Abl impairs mitotic checkpoint and promotes aberrant divisions and resistance to microtubule-targeting agents.

Pub. Date : 2010 May

PMID : 20442314






1 Functional Relationships(s)
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1 Bcr-Abl leads to decreased expression of genes involved in the mitotic checkpoint activation--Mad2, Bub1, Bub3, and BubR1, resulting in mitosis perturbances, weakened mitotic checkpoint function, and mitotic slippage after nocodazole treatment. Nocodazole mitotic arrest deficient 2 like 1 Homo sapiens