Title : Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2.

Pub. Date : 2010 Apr 6

PMID : 20371771






2 Functional Relationships(s)
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1 Here, we show that, whereas MRAP was essential for activation of MC2R signaling, MRAP2 was an endogenous inhibitor that competed with MRAP for binding to MC2R and decreased the potency of adrenocorticotropic hormone (ACTH), the endogenous agonist for MC2Rs, in stimulating the production of adenosine 3",5"-monophosphate (cAMP). Cyclic AMP proopiomelanocortin Homo sapiens
2 Here, we show that, whereas MRAP was essential for activation of MC2R signaling, MRAP2 was an endogenous inhibitor that competed with MRAP for binding to MC2R and decreased the potency of adrenocorticotropic hormone (ACTH), the endogenous agonist for MC2Rs, in stimulating the production of adenosine 3",5"-monophosphate (cAMP). Cyclic AMP proopiomelanocortin Homo sapiens