Title : Bortezomib potentially inhibits cellular growth of vascular endothelial cells through suppression of G2/M transition.

Pub. Date : 2010 Jun

PMID : 20367638






3 Functional Relationships(s)
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1 A further analysis of cell cycle-related proteins revealed that bortezomib increased the expression levels of cyclin B1, the cdc2/cyclin B complex, and the phosphorylation of all T14, Y15, and T161 residues on cdc2. Bortezomib cyclin dependent kinase 1 Homo sapiens
2 A further analysis of cell cycle-related proteins revealed that bortezomib increased the expression levels of cyclin B1, the cdc2/cyclin B complex, and the phosphorylation of all T14, Y15, and T161 residues on cdc2. Bortezomib cyclin dependent kinase 1 Homo sapiens
3 Bortezomib also increased the ubiquitination of cyclin B1 and wee1, but inhibited the kinase activity of the cdc2/cyclin B complex. Bortezomib cyclin dependent kinase 1 Homo sapiens