Title : Nicotine induces resistance to chemotherapy in nasal epithelial cancer.

Pub. Date : 2010 Mar-Apr

PMID : 20338106






3 Functional Relationships(s)
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1 Furthermore, nicotine induced activation of AKT and MAPK pathways, while inhibition of MAPK using U0126 and AKT by phosphatidylinositol 3-kinase inhibitor, LY294002, in part, blocked the antiapoptotic effects of nicotine against cisplatin and etoposide-induced apoptosis in NC. Nicotine AKT serine/threonine kinase 1 Homo sapiens
2 Furthermore, nicotine induced activation of AKT and MAPK pathways, while inhibition of MAPK using U0126 and AKT by phosphatidylinositol 3-kinase inhibitor, LY294002, in part, blocked the antiapoptotic effects of nicotine against cisplatin and etoposide-induced apoptosis in NC. Nicotine AKT serine/threonine kinase 1 Homo sapiens
3 CONCLUSION: Nicotine inhibits chemotherapy-induced apoptosis in NC via the AKT and MAPK-mediated signaling pathways. Nicotine AKT serine/threonine kinase 1 Homo sapiens