Title : Radiation-induced bystander signaling pathways in human fibroblasts: a role for interleukin-33 in the signal transmission.

Pub. Date : 2010 Jul

PMID : 20206688






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The NF-kappaB-dependent gene expression of IL8, IL6, PTGS2/COX2, TNF and IL33 in directly irradiated human skin fibroblasts produced the cytokines and prostaglandin E2 (PGE2) with autocrine/paracrine functions, which further activated signaling pathways and induced NF-kappaB-dependent gene expression in bystander cells. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
2 The NF-kappaB-dependent gene expression of IL8, IL6, PTGS2/COX2, TNF and IL33 in directly irradiated human skin fibroblasts produced the cytokines and prostaglandin E2 (PGE2) with autocrine/paracrine functions, which further activated signaling pathways and induced NF-kappaB-dependent gene expression in bystander cells. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
3 As a result, bystander cells also started expression and production of interleukin-8, interleukin-6, COX-2-generated PGE2 and interleukin-33 (IL-33) followed by autocrine/paracrine stimulation of the NF-kappaB and MAPK pathways. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens