Title : Prenatal exposure to the environmental obesogen tributyltin predisposes multipotent stem cells to become adipocytes.

Pub. Date : 2010 Mar

PMID : 20160124






7 Functional Relationships(s)
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Protein Name
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1 Tributyltin (TBT) is an agonist of both retinoid X receptor (RXR) and peroxisome proliferator-activated receptor gamma (PPARgamma). tributyltin peroxisome proliferator activated receptor gamma Mus musculus
2 Tributyltin (TBT) is an agonist of both retinoid X receptor (RXR) and peroxisome proliferator-activated receptor gamma (PPARgamma). tributyltin peroxisome proliferator activated receptor gamma Mus musculus
3 Tributyltin (TBT) is an agonist of both retinoid X receptor (RXR) and peroxisome proliferator-activated receptor gamma (PPARgamma). tributyltin peroxisome proliferator activated receptor gamma Mus musculus
4 Tributyltin (TBT) is an agonist of both retinoid X receptor (RXR) and peroxisome proliferator-activated receptor gamma (PPARgamma). tributyltin peroxisome proliferator activated receptor gamma Mus musculus
5 The adipogenic effects of TBT and rosiglitazone were blocked by the addition of PPARgamma antagonists, suggesting that activation of PPARgamma mediates the effect of both compounds on adipogenesis. tributyltin peroxisome proliferator activated receptor gamma Mus musculus
6 The adipogenic effects of TBT and rosiglitazone were blocked by the addition of PPARgamma antagonists, suggesting that activation of PPARgamma mediates the effect of both compounds on adipogenesis. tributyltin peroxisome proliferator activated receptor gamma Mus musculus
7 ADSCs retrieved from animals exposed to TBT in utero showed increased expression of PPARgamma target genes such as the early adipogenic differentiation gene marker fatty acid-binding protein 4 and hypomethylation of the promoter/enhancer region of the fatty acid-binding protein 4 locus. tributyltin peroxisome proliferator activated receptor gamma Mus musculus