Title : Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.

Pub. Date : 2010 Apr 9

PMID : 20154087






1 Functional Relationships(s)
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1 We found that celastrol also induced reactive oxygen species (ROS) generation, and ROS sequestration inhibited celastrol-induced expression of CHOP and DR5, and consequent sensitization to TRAIL. Reactive Oxygen Species TNF receptor superfamily member 10b Homo sapiens