Title : 3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. part 2: optimization of the side chains to improve in vitro and in vivo potencies.

Pub. Date : 2010 Feb 15

PMID : 20129791






1 Functional Relationships(s)
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1 Several compounds, which showed excellent subtype selectivity, were evaluated for their inhibitory effect against PGE(2)-induced uterine contraction in pregnant rats, which is thought to be mediated by the EP3 receptor subtype. Dinoprostone prostaglandin E receptor 3 Rattus norvegicus