Title : Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis.

Pub. Date : 2010 Apr

PMID : 20068134

1 Functional Relationships(s)
Compound Name
Protein Name
1 RESULTS: Upregulation of Socs3 in POMC neurons leads to impairment of STAT3 and mammalian target of rapamycin (mTOR)-S6K-S6 signaling, with subsequent leptin resistance, obesity, and glucose intolerance. Glucose proopiomelanocortin Homo sapiens