Title : Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis.

Pub. Date : 2010 Apr

PMID : 20068134






1 Functional Relationships(s)
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1 RESULTS: Upregulation of Socs3 in POMC neurons leads to impairment of STAT3 and mammalian target of rapamycin (mTOR)-S6K-S6 signaling, with subsequent leptin resistance, obesity, and glucose intolerance. Glucose proopiomelanocortin Homo sapiens