Title : Trends in substrate hydroxylation reactions by heme and nonheme iron(IV)-oxo oxidants give correlations between intrinsic properties of the oxidant with barrier height.

Pub. Date : 2010 Jan 27

PMID : 20041691






1 Functional Relationships(s)
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1 We show that the hydrogen atom abstraction barrier of substrate hydroxylation correlates linearly with the strength of the Fe(III)O-H bond that is formed, i.e., BDE(OH), and that this value ranges by at least 20 kcal mol(-1) dependent on the cis- and trans-ligands attached to the metal. Metals homeobox D13 Homo sapiens