Pub. Date : 2010 Apr
PMID : 20039267
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bone morphogenetic protein 2 and dexamethasone synergistically increase alkaline phosphatase levels through JAK/STAT signaling in C3H10T1/2 cells. | Dexamethasone | signal transducer and activator of transcription 3 | Mus musculus |
| 2 | A luciferase assay using ALP promoter deletion constructs showed that a region of the promoter containing a putative signal transducer and activator of transcription 3 (STAT3) response element (SRE) responds to treatment with a combination of BMP-2 and Dex. | Dexamethasone | signal transducer and activator of transcription 3 | Mus musculus |
| 3 | A luciferase assay using ALP promoter deletion constructs showed that a region of the promoter containing a putative signal transducer and activator of transcription 3 (STAT3) response element (SRE) responds to treatment with a combination of BMP-2 and Dex. | Dexamethasone | signal transducer and activator of transcription 3 | Mus musculus |
| 4 | In addition, a STAT3 siRNA suppressed the synergistic effect of BMP-2 and Dex on ALP levels. | Dexamethasone | signal transducer and activator of transcription 3 | Mus musculus |
| 5 | To our knowledge, this is the first time that STAT3 has been implicated in the regulation of ALP expression by BMP-2 and Dex. | Dexamethasone | signal transducer and activator of transcription 3 | Mus musculus |