Pub. Date : 2010 Jan 27
PMID : 19928918
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Indoleamine 2,3-dioxygenase, an immunomodulatory protein, is suppressed by (-)-epigallocatechin-3-gallate via blocking of gamma-interferon-induced JAK-PKC-delta-STAT1 signaling in human oral cancer cells. | epigallocatechin gallate | signal transducer and activator of transcription 1 | Homo sapiens |
| 2 | The study results demonstrate that EGCG can inhibit translocation of STAT1 into nucleus in IFN-gamma-stimulated human oral cancer cells. | epigallocatechin gallate | signal transducer and activator of transcription 1 | Homo sapiens |
| 3 | In addition, both tyrosine and serine phosphorylation of STAT1 are revealed to be suppressed by EGCG. | epigallocatechin gallate | signal transducer and activator of transcription 1 | Homo sapiens |
| 4 | Moreover, phosphorylation of PKC-delta, JAK-1, and JAK-2, which are the upstream event for the activation of STAT1, are also inhibited by EGCG in IFN-gamma-stimulated human oral cancer cells. | epigallocatechin gallate | signal transducer and activator of transcription 1 | Homo sapiens |
| 5 | These data show that EGCG inhibited IDO expression by blocking the IFN-gamma-induced JAK-PKC-delta-STAT1 signaling pathway. | epigallocatechin gallate | signal transducer and activator of transcription 1 | Homo sapiens |