Title : Prolonged Activation of c-fos and Optimal Activation of Pro-opiomelanocortin mRNA after Repeated Morphine Exposure in SH-SY5Y Cells.

Pub. Date : 1993 Feb

PMID : 19912904






5 Functional Relationships(s)
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1 Prolonged Activation of c-fos and Optimal Activation of Pro-opiomelanocortin mRNA after Repeated Morphine Exposure in SH-SY5Y Cells. Morphine proopiomelanocortin Homo sapiens
2 The time course of change in the mRNA concentrations of the proto-oncogene c-fos and pro-opiomelanocortin after two different methods of morphine treatment was examined in SH-SY5Y human neuroblastoma cells. Morphine proopiomelanocortin Homo sapiens
3 Slot-blotting hybridization with a [(32)P]-POMC cRNA probe revealed that POMC mRNA was significantly activated at 6 h and remained significantly elevated up to 7 days in the cells with repeated morphine treatment. Morphine proopiomelanocortin Homo sapiens
4 Slot-blotting hybridization with a [(32)P]-POMC cRNA probe revealed that POMC mRNA was significantly activated at 6 h and remained significantly elevated up to 7 days in the cells with repeated morphine treatment. Morphine proopiomelanocortin Homo sapiens
5 These results indicate that repeated exposure to morphine induces a prolonged activation of c-fos mRNA which may be functionally related to the significant activation of POMC mRNA in SH-SY5Y cells. Morphine proopiomelanocortin Homo sapiens