Title : Adenosine blocks IFN-gamma-induced phosphorylation of STAT1 on serine 727 to reduce macrophage activation.

Pub. Date : 2009 Nov 15

PMID : 19846878






1 Functional Relationships(s)
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Protein Name
Organism
1 IFN-gamma signaling induces phosphorylation of two STAT1 residues: Tyr(701) (Y701), which facilitates dimerization, nuclear translocation, and DNA binding; and Ser(727) (S727), which enables maximal STAT1 transcription activity. Tyrosine interferon gamma Homo sapiens