Title : Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction.

Pub. Date : 2009 Dec 14

PMID : 19845507






1 Functional Relationships(s)
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1 Moreover, we demonstrate that two conserved IPV (Ile-Pro-Val) motifs in Bag3 mediate its binding to HspB8 and that deletion of these motifs suppresses HspB8 chaperone activity towards mutant Htt43Q (huntingtin exon 1 fragment with 43 CAG repeats). Ile-Pro-Val heat shock protein family B (small) member 8 Homo sapiens