Title : All-trans retinoic acid suppresses Stat3 signaling during skin carcinogenesis.

Pub. Date : 2009 Oct

PMID : 19789299






1 Functional Relationships(s)
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1 Using Western blotting and immunohistochemical staining with phosphospecific antibodies, we show that coadministration of ATRA suppressed the 12-O-tetradecanoylphorbol-13-acetate-induced phosphorylation of Stat3 in both models, but was only able to suppress tumor formation in the SENCAR mice. Tetradecanoylphorbol Acetate signal transducer and activator of transcription 3 Mus musculus