Title : Cholinergic agonists regulate JAK2/STAT3 signaling to suppress endothelial cell activation.

Pub. Date : 2009 Nov

PMID : 19741199






1 Functional Relationships(s)
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1 Treatment of macrovascular human umbilical vein endothelial cells (HUVECs) and microvascular endothelial cells (MVECs) with the cholinergic agonists nicotine and GTS-21 significantly reduced IL-6-mediated monocyte chemoattractant protein-1 (MCP-1) production and ICAM-1 expression which are regulated through the JAK2/STAT3 pathway. Nicotine signal transducer and activator of transcription 3 Homo sapiens