Title : Cholinergic agonists regulate JAK2/STAT3 signaling to suppress endothelial cell activation.

Pub. Date : 2009 Nov

PMID : 19741199

1 Functional Relationships(s)
Compound Name
Protein Name
1 Treatment of macrovascular human umbilical vein endothelial cells (HUVECs) and microvascular endothelial cells (MVECs) with the cholinergic agonists nicotine and GTS-21 significantly reduced IL-6-mediated monocyte chemoattractant protein-1 (MCP-1) production and ICAM-1 expression which are regulated through the JAK2/STAT3 pathway. Nicotine signal transducer and activator of transcription 3 Homo sapiens