Pub. Date : 2009 Dec
PMID : 19732851
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP7B1-mediated metabolism of 5alpha-androstane-3alpha,17beta-diol (3alpha-Adiol): a novel pathway for potential regulation of the cellular levels of androgens and neurosteroids. | Androstane-3,17-diol | cytochrome P450 family 7 subfamily B member 1 | Homo sapiens |
| 2 | The current study presents data indicating that 5alpha-androstane-3alpha,17beta-diol (3alpha-Adiol) undergoes a previously unknown metabolism into hydroxymetabolites, catalyzed by CYP7B1. | Androstane-3,17-diol | cytochrome P450 family 7 subfamily B member 1 | Homo sapiens |
| 3 | 3alpha-Adiol was found to undergo NADPH-dependent metabolism into 6- and 7-hydroxymetabolites in incubations with porcine microsomes and human kidney-derived HEK293 cells, which are high in CYP7B1 content. | Androstane-3,17-diol | cytochrome P450 family 7 subfamily B member 1 | Homo sapiens |
| 4 | In addition, 3alpha-Adiol significantly suppressed CYP7B1-mediated catalytic reactions, in a way as would be expected for substrates that compete for the same enzyme. | Androstane-3,17-diol | cytochrome P450 family 7 subfamily B member 1 | Homo sapiens |
| 5 | Recombinant expression of human CYP7B1 in HEK293 cells significantly increased the rate of 3alpha-Adiol hydroxylation. | Androstane-3,17-diol | cytochrome P450 family 7 subfamily B member 1 | Homo sapiens |