Title : [Effects of the anti-ulcer agents on the amine contents and regulating enzyme activity of gastric mucosa during the healing process of acetic acid induced gastric ulcer in rats].

Pub. Date : 1990 Jan

PMID : 1968027






4 Functional Relationships(s)
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1 The following results were obtained: 1) HDC activity in the gastric mucosa of rats treated with cimetidine (100 mg/kg twice daily) tended to increase in the intact region, and it was significantly increased in the ulcer region. Cimetidine histidine decarboxylase Rattus norvegicus
2 2) Increased HDC activity due to cimetidine treatment was observed at the 10th day after interruption of cimetidine administration. Cimetidine histidine decarboxylase Rattus norvegicus
3 2) Increased HDC activity due to cimetidine treatment was observed at the 10th day after interruption of cimetidine administration. Cimetidine histidine decarboxylase Rattus norvegicus
4 The results suggest that the increased HDC activity in the gastric mucosa might participate in the relapse and recurrence of gastric ulcer after discontinuation of cimetidine administration. Cimetidine histidine decarboxylase Rattus norvegicus