Pub. Date : 2009 Nov
PMID : 19664635
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS: We analyzed the effects of NTZ on the regulation of eukaryotic initiation factor-2alpha (eIF2alpha) and its IFN-induced kinase, protein kinase activated by double-stranded RNA (PKR), in cells that support HCV RNA replication and in vitro biochemical assays. | nitazoxanide | eukaryotic translation initiation factor 2A | Homo sapiens |
| 2 | RESULTS: NTZ increased eIF2alpha phosphorylation, a modification known to mediate host cell antiviral defenses. | nitazoxanide | eukaryotic translation initiation factor 2A | Homo sapiens |
| 3 | The addition of IFN to cell cultures increased NTZ-induced eIF2alpha phosphorylation. | nitazoxanide | eukaryotic translation initiation factor 2A | Homo sapiens |
| 4 | In vitro, NTZ promoted PKR autophosphorylation, a key step in activating PKR"s kinase activity for eIF2alpha. | nitazoxanide | eukaryotic translation initiation factor 2A | Homo sapiens |
| 5 | Finally, NTZ-induced eIF2alpha phosphorylation was reduced in the presence of specific inhibitors of PKR autophosphorylation. | nitazoxanide | eukaryotic translation initiation factor 2A | Homo sapiens |