Title : Docking and 3D-QSAR studies on isatin sulfonamide analogues as caspase-3 inhibitors.

Pub. Date : 2009 Aug

PMID : 19610597






1 Functional Relationships(s)
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1 To provide insight of their inhibition mechanism and facilitate the design of more potent ligands, a series of 59 isatin sulfonamide analogues were docked to the X-ray structure of caspase-3, one of the important cysteine aspartyl-specific execution proteases in apoptosis, and their binding conformations were analyzed by 3D-QSAR studies. Cysteine caspase 3 Homo sapiens