Title : Discovery of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators.

Pub. Date : 2009 Aug 1

PMID : 19540111






1 Functional Relationships(s)
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1 Systematic modification of benzimidazole lead 5a identified from a high-throughput screening led to the discovery of a potent and metabolically stable glucokinase activator 16p(R) with greater structural diversity from GKAs reported to date. benzimidazole glucokinase Rattus norvegicus