Title : Glucose deprivation, oxidative stress and peroxisome proliferator-activated receptor-alpha (PPARA) cause peroxisome proliferation in preimplantation mouse embryos.

Pub. Date : 2009 Sep

PMID : 19531609






2 Functional Relationships(s)
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1 Inhibition of ROS production prevented this induction of PPARA and SLC16A7. Reactive Oxygen Species peroxisome proliferator activated receptor alpha Mus musculus
2 These data suggest that glucose-deprived cleavage stage embryos, although supplied with sufficient monocarboxylate-derived energy, undergo oxidative stress and exhibit elevated ROS, which in turn upregulates PPARA, catalase and SLC16A7 in a classical peroxisomal proliferation response. Reactive Oxygen Species peroxisome proliferator activated receptor alpha Mus musculus