Title : Adrenocorticotrophic hormone (ACTH) responsiveness to ghrelin increases after 6 months of ketoconazole use in patients with Cushing's disease: comparison with GH-releasing peptide-6 (GHRP-6).

Pub. Date : 2010 Jan

PMID : 19453623






4 Functional Relationships(s)
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1 Adrenocorticotrophic hormone (ACTH) responsiveness to ghrelin increases after 6 months of ketoconazole use in patients with Cushing"s disease: comparison with GH-releasing peptide-6 (GHRP-6). Ketoconazole proopiomelanocortin Homo sapiens
2 The effect of clinical treatment of hypercortisolism with ketoconazole on ACTH secretion in CD is controversial. Ketoconazole proopiomelanocortin Homo sapiens
3 CONCLUSIONS: The rise in basal ACTH levels during ketoconazole treatment in CD could be because of the activation of normal corticotrophs, which were earlier suppressed by hypercortisolism. Ketoconazole proopiomelanocortin Homo sapiens
4 The enhanced ACTH responses to ghrelin after ketoconazole in CD could also be due to activation of the hypothalamic-pituitary-adrenal axis and/or to an increase in GHS-receptors expression in the corticotroph adenoma, consequent to reductions in circulating glucocorticoids. Ketoconazole proopiomelanocortin Homo sapiens