Title : Pituitary response to metyrapone in Gulf War veterans: relationship to deployment, PTSD and unexplained health symptoms.

Pub. Date : 2009 Oct

PMID : 19446401






3 Functional Relationships(s)
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1 METHOD: Eleven GWV without PTSD, 18 GWV with PTSD and 15 healthy subjects not exposed to the Gulf War theater (non-exposed) underwent the metyrapone stimulation test, which inhibits cortisol synthesis, impairs cortisol-mediated negative feedback inhibition and in turn increases levels of ACTH and 11-deoxycortisol, a cortisol precursor. Metyrapone proopiomelanocortin Homo sapiens
2 Among GWV, unexplained medical health symptoms (e.g., neurological, musculoskeletal, cardiac, and pulmonary symptoms) and PTSD symptoms were significantly positively associated with the ACTH response to metyrapone. Metyrapone proopiomelanocortin Homo sapiens
3 CONCLUSION: Gulf War deployment is associated with a substantially lower ACTH response to metyrapone. Metyrapone proopiomelanocortin Homo sapiens