Title : Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux.

Pub. Date : 2009 Oct

PMID : 19439761






5 Functional Relationships(s)
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1 Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux. Cholesterol peroxisome proliferator activator receptor delta Mus musculus
2 Activation of PPARdelta markedly increases fecal neutral sterol secretion, the last step in reverse cholesterol transport. Cholesterol peroxisome proliferator activator receptor delta Mus musculus
3 To test the hypothesis that PPARdelta activation leads to stimulation of transintestinal cholesterol efflux (TICE), we quantified it by intestine perfusions in FVB mice treated with PPARdelta agonist GW610742. Cholesterol peroxisome proliferator activator receptor delta Mus musculus
4 Interestingly, expression of Rab9 and LIMPII, encoding proteins involved in intracellular cholesterol trafficking, was increased upon PPARdelta activation. Cholesterol peroxisome proliferator activator receptor delta Mus musculus
5 These data show that activation of PPARdelta stimulates fecal cholesterol excretion in mice, primarily by the two-fold increase in TICE, indicating that this pathway provides an interesting target for the development of drugs aiming at the prevention of atherosclerosis. Cholesterol peroxisome proliferator activator receptor delta Mus musculus