Title : Variable inhibitory effect of different brands of commercial herbal supplements on human cytochrome P-450 CYP3A4.

Pub. Date : 2009

PMID : 19353999






2 Functional Relationships(s)
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1 Aliquots of the extract were tested for their ability to inhibit the metabolism of the human CYP3A4 probe quinine, using an in vitro liver microsomal technique. Quinine cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Formation of quinine"s metabolite 3-hydroxyquinine, generated by the CYP3A4-mediated reaction, was measured by HPLC. Quinine cytochrome P450 family 3 subfamily A member 4 Homo sapiens