Title : Alpha-melanocyte-stimulating hormone counteracts the suppressive effect of UVB on Nrf2 and Nrf-dependent gene expression in human skin.

Pub. Date : 2009 Jul

PMID : 19282378






2 Functional Relationships(s)
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1 This effect of alpha-MSH occurred at physiological doses and was due to transcriptional induction, mimicked by the artificial cAMP inducer forskolin, and blocked by protein kinase A pathway inhibition. Cyclic AMP proopiomelanocortin Homo sapiens
2 In silico promoter analysis of Nrf2 further identified several putative binding sites for activator protein 1 and cAMP response element-binding protein, transcription factors typically activated by alpha-MSH. Cyclic AMP proopiomelanocortin Homo sapiens