Title : Overexpression of visfatin/PBEF/Nampt alters whole-body insulin sensitivity and lipid profile in rats.

Pub. Date : 2009

PMID : 19263259






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Consistent with the clamp data, the extent of insulin receptor substrate (IRS)-1 tyrosine phosphorylation in response to insulin was significantly enhanced in the liver and adipose tissues. Tyrosine insulin receptor substrate 1 Rattus norvegicus
2 CONCLUSION: These results demonstrate that visfatin/PBEF/Nampt improves insulin sensitivity and exerts its hypocholesterolemic effects at least partially through upregulation of the tyrosine phosphorylation of IRS-1 protein and the mRNA levels of PPARgamma and SREBP-2. Tyrosine insulin receptor substrate 1 Rattus norvegicus