Title : Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway.

Pub. Date : 2009 Apr 24

PMID : 19254698






3 Functional Relationships(s)
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1 Adiponectin, one of the insulin-sensitizing adipokines, has been shown to activate fatty acid oxidation in liver and skeletal muscle, thus maintaining insulin sensitivity. Fatty Acids adiponectin, C1Q and collagen domain containing Mus musculus
2 However, the precise roles of adiponectin in fatty acid synthesis are poorly understood. Fatty Acids adiponectin, C1Q and collagen domain containing Mus musculus
3 Here we show that adiponectin administration acutely suppresses expression of sterol regulatory element-binding protein (SREBP) 1c, the master regulator which controls and upregulates the enzymes involved in fatty acid synthesis, in the liver of +Lepr(db)/+Lepr(db) (db/db) mouse as well as in cultured hepatocytes. Fatty Acids adiponectin, C1Q and collagen domain containing Mus musculus