Title : Effect of chronic nicotine treatment and its withdrawal on the vasopressinergic system in rats.

Pub. Date : 1991 Feb 1

PMID : 19215455






6 Functional Relationships(s)
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1 Treatment with the high dose of chronic nicotine alone decreased vasopressin content in and release from the neural lobe and its plasma concentration, but it did not change significantly the vasopressin content in the hypothalamus. Nicotine arginine vasopressin Rattus norvegicus
2 A similar pattern of changes in vasopressin release and plasma concentration, though less pronounced, was observed in the rats infused with the low dose of nicotine. Nicotine arginine vasopressin Rattus norvegicus
3 The withdrawal of the high dose of chronic nicotine gradually returned the decreased plasma vasopressin concentration, and its content in and release from the neural lobe to control values within 2 weeks. Nicotine arginine vasopressin Rattus norvegicus
4 However, vasopressin content in the hypothalamus started to decline 1 week after nicotine withdrawal and persisted to decline for at least 3 subsequent weeks. Nicotine arginine vasopressin Rattus norvegicus
5 The withdrawal of the low dose of nicotine exhibited a significant decline in plasma vasopressin concentration for up to 2 weeks only following chronic nicotine withdrawal, tending to return subsequently to control levels. Nicotine arginine vasopressin Rattus norvegicus
6 The withdrawal of the low dose of nicotine exhibited a significant decline in plasma vasopressin concentration for up to 2 weeks only following chronic nicotine withdrawal, tending to return subsequently to control levels. Nicotine arginine vasopressin Rattus norvegicus