Title : Quantitative Comparisons Between the Electrical Activity of Supraoptic Neurons and Vasopressin Release in vitro.

Pub. Date : 1989 Jun 1

PMID : 19210458






3 Functional Relationships(s)
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1 Phenylephrine caused a dose-dependent release of vasopressin into the perifusate and a dose-dependent increase in the peak firing rate, initial burst duration and the total number of action potentials (compared to a 10 min control period) of the recorded neurons. Phenylephrine arginine vasopressin Rattus norvegicus
2 Peak firing rate and peak vasopressin release both increased linearly with the log of the phenylephrine dose, but the efficiency ratio of the increase in vasopressin release to the increase in firing rate was greater from the middle to the highest dose than it was for the lowest to the middle dose, indicating a possible facilitation of hormone release with higher firing frequencies. Phenylephrine arginine vasopressin Rattus norvegicus
3 In another group of explants the temporal relationship between firing rate and vasopressin release was examined after a single dose of 1 mM phenylephrine. Phenylephrine arginine vasopressin Rattus norvegicus