Title : [Epigallocatechin-3-gallate inhibits growth and angiogenesis of gastric cancer and its molecular mechanism].

Pub. Date : 2009 Jan

PMID : 19145512






3 Functional Relationships(s)
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1 Stat3 activation was dose-dependently suppressed by EGCG in tumor cells, and an average of 53.5% reduction was observed in tumor tissues, but EGCG treatment did not change total Stat3 expression. epigallocatechin gallate signal transducer and activator of transcription 3 Mus musculus
2 Stat3 activation was dose-dependently suppressed by EGCG in tumor cells, and an average of 53.5% reduction was observed in tumor tissues, but EGCG treatment did not change total Stat3 expression. epigallocatechin gallate signal transducer and activator of transcription 3 Mus musculus
3 CONCLUSION: EGCG reduces expression of VEGF in gastric cancer by inhibiting activation of Stat3, thereby inhibits tumor growth and angiogenesis of gastric cancer. epigallocatechin gallate signal transducer and activator of transcription 3 Mus musculus