Title : Regulation of T-cell function by endogenously produced angiotensin II.

Pub. Date : 2009 Feb

PMID : 19073907






2 Functional Relationships(s)
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1 We found that superoxide was a critical mediator of T-cell TNF-alpha production, as this was significantly inhibited by polyethylene glycol (PEG)-SOD, but not PEG-catalase. Superoxides tumor necrosis factor Mus musculus
2 Thus, T cells contain an endogenous renin-angiotensin system that modulates T-cell function, NADPH oxidase activity, and production of superoxide that, in turn, modulates TNF-alpha production. Superoxides tumor necrosis factor Mus musculus