Title : Characterization, chemical optimization and anti-tumour activity of a tubulin poison identified by a p53-based phenotypic screen.

Pub. Date : 2008 Nov 1

PMID : 18971638






1 Functional Relationships(s)
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1 The effects of nocodazole, a well established tubulin poison, and JJ78:12 on p53 levels are remarkably similar, supporting that tubulin depolymerization is the main mechanism by which JJ78:12 treatment leads to p53 activation in cells. Nocodazole transformation related protein 53, pseudogene Mus musculus