Title : Superoxide produced by Kupffer cells is an essential effector in concanavalin A-induced hepatitis in mice.

Pub. Date : 2008 Dec

PMID : 18942689






2 Functional Relationships(s)
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1 Anti-TNF antibody (Ab) pretreatment did not inhibit the increase of Kupffer cells, but it effectively suppressed superoxide/reactive oxygen production from Kupffer cells and the resulting hepatic injury. Superoxides tumor necrosis factor Mus musculus
2 CONCLUSION: Superoxide produced by Kupffer cells may be the essential effector in Con-A hepatitis, and TNF and NKT cells support their activation and superoxide production. Superoxides tumor necrosis factor Mus musculus