Title : Nicotine-induced alterations in peripheral tissue concentrations of native and cryptic Met- and Leu-enkephalin.

Pub. Date : 1991 May

PMID : 1891072






4 Functional Relationships(s)
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1 Subacute nicotine decreased splenic concentrations of native and cryptic Met-enkephalin and native Leu-enkephalin, consistent with increased release of Met- and Leu-enkephalin from spleen and decreased synthesis of proenkephalin A or inadequate processing of larger peptides to enkephalin pentapeptides in spleen to compensate for the increased release during this period. Nicotine proopiomelanocortin Homo sapiens
2 HPLC characterization revealed that nicotine-induced decrease in native Met-enkephalin in spleen resulted from reductions in both pentapeptide and its sulfoxide. Nicotine proopiomelanocortin Homo sapiens
3 Nicotine also increased native Met-enkephalin in jejunum, decreased cryptic Met-enkephalin in heart atrium, increased native Leu-enkephalin in anterior pituitary and decreased cryptic Leu-enkephalin in jejunum. Nicotine proopiomelanocortin Homo sapiens
4 Nicotine also increased native Met-enkephalin in jejunum, decreased cryptic Met-enkephalin in heart atrium, increased native Leu-enkephalin in anterior pituitary and decreased cryptic Leu-enkephalin in jejunum. Nicotine proopiomelanocortin Homo sapiens