Title : The beta-galactoside binding immunomodulatory lectin galectin-3 reverses the desensitized state induced in neutrophils by the chemotactic peptide f-Met-Leu-Phe: role of reactive oxygen species generated by the NADPH-oxidase and inactivation of the agonist.

Pub. Date : 2008 Nov

PMID : 18725453






2 Functional Relationships(s)
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1 The effect was inhibited by the competitor lactose and required the affinity of galectin-3 for N-acetyllactosamine, a saccharide typically found on cell surface glycoproteins. N-acetyllactosamine galectin 3 Homo sapiens
2 The latter was shown using a galectin-3 mutant that lacked N-acetyllactosamine binding activity, and this protein was not active. N-acetyllactosamine galectin 3 Homo sapiens